The expression of astroglial glutamate transporters in patients with focal cortical dysplasia: an immunohistochemical study

Ulu M. O. , Tanriverdi T. , Oz B. , Biceroglu H., Isler C. , ERASLAN B. S. , ...More

ACTA NEUROCHIRURGICA, vol.152, no.5, pp.845-853, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 152 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.1007/s00701-009-0548-2
  • Title of Journal : ACTA NEUROCHIRURGICA
  • Page Numbers: pp.845-853

Abstract

An abnormal increase in the extracellular glutamate is thought to play a crucial role in the initiation, spread, and maintenance of seizure activity.In normal conditions, the majority of this excess glutamate is cleared via glial glutamate transporters (EAAT-1 and EAAT-2). We aimed to examine the immunohistochemical expression of these transporters in the dysplastic tissues of patients with focal cortical dysplasia (FCD).