The expression of astroglial glutamate transporters in patients with focal cortical dysplasia: an immunohistochemical study

Ulu M. O., Tanriverdi T., Oz B., Biceroglu H., Isler C., ERASLAN B. S., ...Daha Fazla

ACTA NEUROCHIRURGICA, cilt.152, sa.5, ss.845-853, 2010 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 152 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s00701-009-0548-2
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.845-853
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

An abnormal increase in the extracellular glutamate is thought to play a crucial role in the initiation, spread, and maintenance of seizure activity.In normal conditions, the majority of this excess glutamate is cleared via glial glutamate transporters (EAAT-1 and EAAT-2). We aimed to examine the immunohistochemical expression of these transporters in the dysplastic tissues of patients with focal cortical dysplasia (FCD).