Cerebellar volume loss in radiologically isolated syndrome

George I. C., El Mendili M. M., Inglese M., Azevedo C. J., Kantarci O., Lebrun C., ...Daha Fazla

Multiple Sclerosis Journal, cilt.27, sa.1, ss.130-133, 2021 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1177/1352458519887346
  • Dergi Adı: Multiple Sclerosis Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.130-133
  • Anahtar Kelimeler: Radiologically isolated syndrome, multiple sclerosis, cerebellum, brainstem, cerebellar atrophy, white matter lesions, MULTIPLE-SCLEROSIS
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

© The Author(s), 2019.Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC (p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.