Limited stage small cell lung cancer: Treatment results and prognostic factors

Yildirim, HALİL; Ergen, ŞEFİKA; Tiken, Elif; Zalova, Gunel; Turna, ZEYNEP; Oksuz, DİDEM; Oner Dincbas, HİDAYET

doi:10.5505/tjoncol.2015.1353

Limited stage small cell lung cancer: Treatment results and prognostic factors

Yildirim H. C., Ergen S. A., Tiken E. E., Zalova G., Turna H., Oksuz D., ...Daha Fazla

TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY, sa.4, ss.188-194, 2015 (ESCI, Scopus)

Yayın Türü: Makale / Tam Makale
Basım Tarihi: 2015
Doi Numarası: 10.5505/tjoncol.2015.1353
Dergi Adı: TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY
Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
Sayfa Sayıları: ss.188-194
İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

OBJECTIVES To evaluate the treatment results and prognostic factors in patients with limited stage small cell lung cancer patients, retrospectively. METHODS Fifty-two patients with limited stage small cell lung cancer treated between 2005 and 2012, in our hospital were retrospectively evaluated. RESULTS The 2-year overall survival and disease free survival rates were 48% and 15%. On univariate analysis T1 tumor (p=.012), concomittant chemoradiotherapy (p=.023), start of radiotherapy within the 3 months after diagnosis (p=.026) and prophylactic cranial irradiation (p=.025) significantly improved disease free survival rate. Concomittant chemoradiotherapy (p<.001), early radiotherapy (p<.001) and prophylactic cranial irradiaton (p=.001) significantly affected overall survival rate. On multivariate analysis, only prophylactic cranial irradiation was found to be an independent factor affecting overall survival rate (p=.003). CONCLUSION Our results were consistent with the literature even though small sample size. Prophylactic cranial irradiation was determined the only independent factor that affects overall survival.