STAT1/STAT3 Gain of Function and Mechanisms of Immune Dysregulation
TURKISH JOURNAL OF IMMUNOLOGY, vol.12, pp.47-52, 2024 (ESCI, Scopus, TRDizin)
- Publication Type: Article / Review
- Volume: 12
- Publication Date: 2024
- Doi Number: 10.4274/tji.galenos.2023.52386
- Journal Name: TURKISH JOURNAL OF IMMUNOLOGY
- Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, TR DİZİN (ULAKBİM)
- Page Numbers: pp.47-52
- Open Archive Collection: AVESIS Open Access Collection
- Istanbul University-Cerrahpasa Affiliated: Yes
Abstract
The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling pathways are essential for maintaining prompt immune responses to various cytokines. Both loss- and gain-of-function mutations in the JAK and STAT molecules result in different disease profiles in inborn errors of immunity. The discovery of gain-of-function mutations in STAT1 and STAT3 expanded immunological investigations aimed at understanding both signaling pathways and their associated disorders. Both defects are distinct from loss-of-function mutations that lead to alterations in immune regulation. In this context, we wanted to take a look at both diseases and focus on the mechanisms.