Challenges in Rhinology, Cemal Cingi,Nuray Bayar Muluk,Gle,is K Scadding,Ranko Mladina, Editör, Springer-Verlag , Zürich, ss.429-438, 2020
Chronic cough is generally defined as a cough of over 8-week duration. For the purposes of this chapter, we will consider patients as having had a normal chest X-ray and spirometry as first-line investigations for their cough. Clinicians may incorrectly conclude, on the basis that the cough does not respond to pharmacotherapy, that its basis is functional, i.e. psychological in nature. There are several factors which render the treatment of cough challenging. In a number of individuals, an insufficiently comprehensive diagnostic workup, without due attention to causes both within and outside the lung, may cause treatment problems. In others, pharmacotherapy may involve doses that are too low, or the course may be too short. There is evidence that chronic coughing can lead to the development of increased sensitivity of the cough reflex, leading to exaggerated cough responses and what has come to be known as cough hypersensitivity syndrome (CHS).