Akademik Veri Yönetim Sistemi
AEPC 2018, Athens, Yunanistan, 09 Mayıs 2018 - 14 Mart 2020, ss.4, (Özet Bildiri)
Eroglu A.G., Atik S.U., Cinar B., Bakar M. T., Saltik I.L.
Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey
Introduction: In this study, we evaluated the natural history and the factors effecting the progression of
aortic valvular stenosis (AVS) and aortic regurgitation (AR) in 388 patients during long term follow-up
by echocardiography.
Methods: Very mild aortic stenosis was defined as a transvalvular Doppler gradient less than 25
mmHg, mild stenosis as 25–49 mmHg, moderate stenosis as 50–75 mmHg, and severe stenosis as
more than 75 mmHg.
Results: The patients were followed from 1 month to 20.6 years. The degree of AVS was very mild in
138 (35.6%), mild in 133 (34.3%), moderate in 68 (17.5%) and severe in 49 (12.6%) patients, at the
time of initial echocardiographic examination. Morphologic characteristic of the aortic valve was
unicuspid in 4 (1%), bicuspid in 249 (64%) and tricuspid in 135 (34%) patients. Kaplan-Maier analysis
demonstrated that, the patients with very mild and mild AVS are more likely to survive without AVS
deterioration then the patients with moderate AVS (13.6 years, CI 12-15.1; 15.3 years, CI 14-16.7;
9.8years, CI 8.2-11.5, respectively). Of 388 patients, 148 (38.1%) had AR (50 trivial, 74 mild, 20
moderate, and 4 severe) at initial echocardiographic examination and there was no AR in 240 (61.9%)
patients. No AR developed in 158 (65.8%) of these 240 patients. In 82 (34.2%) AR developed (40
(16.7%) trivial, 32 (13.3% mild, and 10 (4.2%) moderate) after a median 3.2 years, (range 1 month to
16 years) follow-up. During follow up of 148 patients who had AR at initial echocardiography, AR did
not deteriorated in 102 (68.9%) patients and the degree of AR progressed in 46 (31.1%) during a
median 4 years (range: 1 month to 14.2 years) follow up. The bicuspid valve morphology increased
the risk of AR development/deterioration after adjustment for sex (OR 1.73, CI 1-2.7, p=0.022).
Conclussion: Patients with very mild stenosis may be followed with a noninvasive approach every 1 or
2 years, and an annual follow-up is suggested for patients with mild stenosis. We recommend that
patients with moderate stenosis undergo noninvasive evaluation every 6 months.