Comparison of the Outcomes of Four Different Treatment Protocols in Idiopathic Sudden Hearing Loss
MEDITERRANEAN JOURNAL OF OTOLOGY, cilt.4, sa.3, ss.176-183, 2008 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 4 Sayı: 3
- Basım Tarihi: 2008
- Dergi Adı: MEDITERRANEAN JOURNAL OF OTOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.176-183
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır
Özet
OBJECTIVE: To compare effectiveness of four different treatment protocols in idiopathic sudden hearing loss (ISHL). Patients and Methods: The patients with ISHL were divided into four groups according to the treatment protocols applied; Group 1 (n=67) was treated with rheomacrodex, pentoxyphiline, heparin, papaverine, famotidine, and methylprednisolone 1 mg/kg/day iv. Group 2 (n=39), group 3 (n=19) and group 4 (n=60) were treated with acyclovir, famotidine, and methylprednisolone (1 mg/kg/day, 2 mg/kg/day and 3 mg/kg/day, respectively). The symptoms and audiologic parameters were compared between the groups. RESULTS: The PTAs (pure tone averages), and HG (hearing gain), RHG (relative hearing gain) and RR (recovery rate) scores of the groups were not significantly different (p > 0.05). When the commencement of treatment was < 5 days; the HG in group 1 was better than group 3; the RHG in group 4 was better than group 3; and the RR in group 1 was better than group 3 (p < 0.05). When the commencement of treatment was between 5 and 10 days, there was no significant difference between the HG, RHG and RR scores of the groups (p > 0.05). When the commencement of treatment was > 10 days, the HG, RHG and RR scores in group 3 were better than in the other groups (p < 0.05), respectively. CONCLUSION: Overall comparison of the treatment protocols did not reveal significant difference between the outcomes.