The effects of gliclazide on erythrocyte GSH, GSHPx and MDA in streptozotocin-induced diabetic rats STREPTOZOTOSIN INDUKSIYONU ILE DIABET OLUSTURULMUS SICANLARDA GLIKLAZID'IN ERITROSIT LIPID PEROKSIDASYONU, GLUTATYON VE GLUTATYON PEROKSIDAZ DUZEYLERINE ETKISI

Konukoglu D., Celik C., Akcay T., Erensoy N., Yilmazer S., Hatemi H.

Klinik Gelisim, cilt.8, sa.3, ss.3562-3565, 1995 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 3
  • Basım Tarihi: 1995
  • Dergi Adı: Klinik Gelisim
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.3562-3565
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Hayır

Özet

We investigated the effects of gliclazide on erythrocyte GSH, GSHPx and MDA in streptozotocin-induced diabetic rats. In both diabetic groups, mean plasma GSH levels were lower than the control levels (OAD group: 35.31 ± 7.01 mg/100 ml hemolyzate, Diabetic group: 62.18 ± 16.07 mg/100 ml hemolyzate, control group: 101.8 ± 12.9 mg/100 ml hemolyzate). However; GSHPx and MDA levels of OAD group and of diabetic group were:higher than control group (GSHPx levels, 52 ± 3.5 U/gHb, 60 ± 3.9 U/gHb, 45 ± 3.7 U/gHb and MDA levels, 744.8 ± 151.3 nmol/gHb, 1044.66 ± 241.29 nmol/gHb, 491 ± 113 nmol/gHb, respectively). Consequently, it was seen that gliclazide depressed the lipid peroxidation and it call be asserted that it causes more decrease in glutathione levels.