Iloprost reduces colitis induced oxidative stress: An experimental study in rats

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Aytac E., Teksoz S., Saygili S., Tortum O. B., Yavuz N., SÖZER V., ...Daha Fazla

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.24, sa.3, ss.224-229, 2013 (SCI-Expanded, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.4318/tjg.2013.0491
  • Dergi Adı: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.224-229
  • Anahtar Kelimeler: Iloprost, prostacyclin, colitis, experimental, oxidative stress, INFLAMMATORY-BOWEL-DISEASE, ISCHEMIA, TISSUE, EXPRESSION, INJURY, BRAIN, ASSAY
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet

Özet

Background/aims: Reactive oxygen. species have a known potent role in the pathogenesis of ulcerative colitis. Roprost, a pharmaceutical, is a chemically stable derivative of a naturally- occurring human prostacyclin. Several studies have demonstrated protective effects of iloprost via its antioxidant and its anti-inflammatory activity. The aim of this study is to evaluate the effects of iloprost on oxidant/antioxidant status, as well as the large bowel histopathology in experimental colitis. Materials and Method: Forty adult male Wistar-albino rats were randomly divided in to four equal weight-matched groups: sham group (n=10), iloprost administered sham group (n=10), colitis group (n=10), iloprost administered colitis group (n=10). Acetic acid (1 ml of 4% solution) was used to induce colonic inflammation in the rats. Results: Colonic tissue and plasma malondialdehyde levels were significantly lower in the iloprost administered colitis group than the colitis group (p<0.01). Tissue glutathione levels of the iloprost administered colitis group were significantly higher than the colitis group (p<0.001). Conclusion: We have demonstrated in this study iloprost to be an antioxidant, as well as iloprost demonstrating protective activity against colitis induced oxidative stress.