Design, Synthesis, and Biological Evaluation of Novel N-Acyl Sulfonohydrazides Derived From β-Hydroxy Esters: Anticancer, Antioxidant, and Antimicrobial Activities
Chemical Biology and Drug Design, vol.107, no.6, 2026 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 107 Issue: 6
- Publication Date: 2026
- Doi Number: 10.1111/cbdd.70344
- Journal Name: Chemical Biology and Drug Design
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO)
- Keywords: anticancer, antimicrobial, antioxidant, apoptosis assay, sulfonohydrazide
- Istanbul University-Cerrahpasa Affiliated: Yes
Abstract
In this study, a series of novel N-acyl sulfonohydrazides 6a–r derived from β-hydroxy esters was synthesized, and their structures were confirmed through spectroscopic characterization, including FT-IR, 1H NMR, 13C NMR, and HRMS analyses. The anticancer properties of the synthesized compounds were investigated, along with a complementary study evaluating their antioxidant and antimicrobial properties. The cytotoxicity screening against HCT116 and PANC1 cancer cell lines revealed generally low antiproliferative effects; however, compounds 6c and 6e demonstrated relatively higher pro-apoptotic potential in HCT116 cells compared to the other compounds. In assays evaluating antioxidant capacity, utilizing both CUPRAC and DPPH methods, all synthesized compounds exhibited activity ranging from moderate to good. Notably, compound 6l demonstrated the strongest antioxidant performance with TEAC = 1.34 and IC50 = 0.084 ± 0.003 mmol L−1. Furthermore, among the tested compounds, 6a, 6b, and 6d displayed good antibacterial activity against Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 19.53 μg/mL.