Genomics and proteomics
Drug Discovery and One Health Approach in Combating Infectious Diseases, Kanti Bhooshan Pandey,David J. Newman,Chukwuebuka Egbuna, Editör, Elsevier, Massachusetts, ss.239-251, 2025
- Yayın Türü: Kitapta Bölüm / Mesleki Kitap
- Basım Tarihi: 2025
- Yayınevi: Elsevier
- Basıldığı Şehir: Massachusetts
- Sayfa Sayıları: ss.239-251
- Editörler: Kanti Bhooshan Pandey,David J. Newman,Chukwuebuka Egbuna, Editör
- İstanbul Üniversitesi-Cerrahpaşa Adresli: Evet
Özet
The identification of possible therapeutic
targets has been transformed by genomics and proteomics, which have also
improved our comprehension of disease mechanisms and laid the crucial
groundwork for personalized therapy. By examining an organism's entire genetic
makeup, or genomics, scientists can find genetic mutations, variations, and
expression patterns connected to a range of diseases. Genomics helps researchers
focus on therapeutic targets that are genetically related to disease by
identifying genes linked to particular disorders through technologies like
next-generation sequencing. Proteomics, the study of all proteins found in
cells, tissues, or organisms, complementarily sheds light on the structure,
function, relationships, and post-translational changes of proteins. Proteomics
makes it possible to examine the cellular networks and biochemical processes
that are disturbed in disease, identifying new areas for therapeutic
intervention. The integration of genomics and proteomics offers a comprehensive
approach to understanding complex biological processes and identifying precise
molecular targets for drug development. By customizing therapy for each patient
according to their genetic and proteomic profiles, these fields propel
personalized medicine and produce less harmful and more effective treatments.
Finding actionable targets and biomarkers is now possible thanks to recent
developments in bioinformatics and data integration, which have improved the
processing of proteomics and genomics data. In the end, a new era in drug
discovery and illness treatment is supported by the confluence of proteomics
and genomics, opening the door for precision healthcare solutions that are
tailored to each patient's unique needs using genetic data.