Synthesis and Clarification of Some New Xanthene Derivatives

5th Organic Chemistry Congress 2021 - OrgChemTR-5, Malatya, Türkiye, 14 - 17 Ekim 2021, ss.54, (Özet Bildiri)

The synthesis of xanthenes has increased remarkably in recent years due to their wide range of biological and pharmacological

properties. Xanthenes are important biologically active oxygen-containing heterocyclic compounds. These types of

compounds have some biological and pharmacological properties, such as anticarcinogenic [1], antiviral [2], antibacterial [3],

and anti-inflammatory [4]. Because of their pharmaceutical activity, they are used in photodynamic therapy [5].

In this study, firstly, new derivatives (substituted 9-arylxanthenes) of xanthene compounds with important biological activities

were synthesized by developing a new synthesis method. In order to obtain xanthene derivatives, the original alkene

compounds to be used as the starting point were synthesized in 4 steps using appropriate reactions. In order to obtain the

desired xanthene derivatives, ring closure reaction was carried out by intramolecular Friedel-Crafts alkylation of the

synthesized starting compounds, the appropriate alkene compounds. This method is unique with the development of suitable

catalyst and reaction conditions. As a result, an alkene compound was used in the synthesis of xanthene through ring closure

by activating it for the first time.

Using the newly developed method, 12 substituted 9-arylxanthene derivatives with original structures and possible biological

activity were synthesized. The structures of the synthesized compounds were illuminated by FT-IR, 1H-NMR, 13C-NMR and

GC/MS.