Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury

Colak A., Karaoglan A., Barut S., Kokturk S., Akyildiz A., Tasyurekli M.

JOURNAL OF NEUROSURGERY-SPINE, vol.2, no.3, pp.327-334, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 3
  • Publication Date: 2005
  • Doi Number: 10.3171/spi.2005.2.3.0327
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.327-334
  • Istanbul University-Cerrahpasa Affiliated: No


Object. Apoptosis is considered one of the most significant mechanisms in the pathogenesis of neuronal damage after spinal cord injury (SCI). This form of cell death occurs via mediators known as caspases. The aim of this study was to evaluate the neuroprotective effect of the caspase-9 inhibitor, z-LEHD-fmk, in a rat model of spinal cord trauma.