Immunohistochemical, apoptotic and biochemical changes by dipeptidyl peptidase-4 inhibitor-sitagliptin in type-2 diabetic rats

Karabulut S., Coskun Z. M., Bolkent S.

PHARMACOLOGICAL REPORTS, vol.67, no.5, pp.846-853, 2015 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.1016/j.pharep.2015.01.010
  • Journal Name: PHARMACOLOGICAL REPORTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.846-853
  • Keywords: Apoptosis, Rat, Sitagliptin, Type-2 diabetes, Pancreas, GLUCAGON-LIKE PEPTIDE-1, BETA-CELL MASS, OXIDATIVE STRESS, RECEPTOR AGONISTS, DPP-4 INHIBITOR, IV INHIBITOR, NEONATAL-RAT, STREPTOZOTOCIN, EXPRESSION, REGENERATION
  • Istanbul University-Cerrahpasa Affiliated: No

Abstract

Background: Diabetes is a major public health problem that is rapidly increasing in prevalence. In this study, the effects of sitagliptin, a dipeptidyl peptidase-4 inhibitor, were examined on newborn diabetic rat model.