IN-VIVO QUANTIFICATION OF MUSCLE DAMAGE IN DOGS AFTER INTRAMUSCULAR ADMINISTRATION OF DRUGS

AKTAS M. , VINCLAIR P., LEFEBVRE H., TOUTAIN P., BRAUN J.

BRITISH VETERINARY JOURNAL, vol.151, no.2, pp.189-196, 1995 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 151 Issue: 2
  • Publication Date: 1995
  • Doi Number: 10.1016/s0007-1935(95)80010-7
  • Title of Journal : BRITISH VETERINARY JOURNAL
  • Page Numbers: pp.189-196

Abstract

Intramuscular injections of a vitamin B preparation, imidocarb, imidocarb+lidocaine, and a preparation of salts of fatty acids produced significant increases in plasma creatine kinase activity in groups of five to six dogs. Activities peaked between 3 and 8 h, and were as high as 23 times base values with the fatty acid salts preparation. Quantification of the equivalent muscle damage gave means of 0.04, 0.25, 0.23 and 0.30 g kg(-1) body weight, respectively, for each of the above preparations.