Investigation of PhiKZ phage therapy against Pseudomonas aeruginosa in mouse pneumonia model

Can K. , Aksu U., Yenen O. S.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.48, no.3, pp.670-678, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.3906/sag-1711-22
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.670-678
  • Keywords: Phage therapy, bacterial load, Pseudomonas aeruginosa PAO1, PhiKZ phage, pneumonia, mice model, BACTERIOPHAGE THERAPY, STAPHYLOCOCCUS-AUREUS, INFECTIONS, EFFICACY, MICE, ANTIBIOTICS, SEPTICEMIA

Abstract

Background/aim: The aim of this study was to investigate the effects of PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the Pseudomonas aeruginosa PAO1 strain. The cross- talk between lungs and kidneys was also determined.