COVID-19 Hastalarında Povidon İyot ile Nazal İrrigasyonun Nazofarengeal Viral Yük Üzerine Etkisi
Çakan D., Batıoğlu Karaaltın A. (Yürütücü)
Yükseköğretim Kurumları Destekli Proje, BAP Araştırma Projesi, 2021 - 2022
- Proje Türü: Yükseköğretim Kurumları Destekli Proje
- Destek Programı: BAP Araştırma Projesi
- Başlama Tarihi: Haziran 2021
- Bitiş Tarihi: Eylül 2022
Proje Özeti
Objective: This study was aimed to invastigate the in vivo virucidal activity of nasal irrigation with saline, nasal irrigation with PVP-I 1%, nasal irrigation with hypertonic alkaline and nasal irrigation with PVP-I 1% against SARS CoV- 2.
Material and methods: One hundred twenty SARS-CoV-2 positive patients were included and divided into four groups. Standard COVID-19 treatment was given to group 1(n=30), standart treatment plus nasal irrigation containing isotonic solution in group 2 (n=30), standart treatment plus nasal irrigation containing 1% PVP solution in group3(n=30), standart treatment plus nasal irrigation containing 1% PVP solution prepared with hypertonic alkaline solution in group 4(n=30). Nasopharyngeal swab samples were collected from subjects on the first day of diagnosis (day 0), the 3rd and 5th days and the nasopharyngeal viral load decrease analyzed with quantitative RT-PCR.
Results: Nasopharyngeal viral load decrease was statistically significant for four groups, when the difference between nasopharyngeal viral load 0-3rd Day and 0-5th day were compared (p< 0.05). In paired comparisons of groups, the nasopharyngeal viral load decrease in group 4 in first 3 days was significantly lower than all groups (p < 0.05). The nasopharyngeal viral load degrease in groups 3 and 4 in the first 5 days were significantly lower than group 1 (p < 0.05)
Conclussion: This study was reveal that the use of hypertonic alkaline nasal irrigation together with 1% povidone-iodine was more effective in reducing viral load in the early period and may be promising modality to prevent the COVID-19 epidemic.
Key words: COVID-19, nasopharyngeal viral load, povidone iodine, hypertonic alkaline solution